If museums are on your list of things to see in Sde Boker, then you might want to head to Ben-Gurion House. If you want to experience more of the culture Sde Boker has to offer, head to Ben-Gurion's Tomb.
You can spend an afternoon studying the exhibits at Makhtesh Ramon Visitors Center during your trip to Mitzpe Ramon. Discover the area's desert landscape and seek out the hiking trails.